Expect small bumps at injection points for up to 72 hours, and possible mild redness/tenderness.

Can I have NEWEST if I have a fish allergy?

Because it’s fish-derived, we’ll discuss allergy history and recommend alternatives if needed.

NEWEST Polynucleotides + Hyaluronic Acid in Berkhamsted

At Dermaline Aesthetics, we offer NEWEST by Mastelli — a unique injectable that combines polynucleotides with hyaluronic acid (HA) to improve hydration, elasticity and overall skin health with natural-looking results.

What is NEWEST?

NEWEST is the only UK treatment pairing regenerative polynucleotides with hydrating hyaluronic acid in a single protocol. It focuses on skin quality rather than adding bulk.

How polynucleotides support repair

Polynucleotides signal fibroblasts to support collagen and elastin, encouraging cellular-level renewal. Mastelli’s NEWEST uses highly purified, fish-derived DNA fragments that are injected into the dermis to aid regeneration.

NEWEST by Mastelli – polynucleotides and hyaluronic acid skin booster for hydrated, firmer skin at Dermaline Aesthetics Berkhamsted

NEWEST combines polynucleotides with hyaluronic acid to boost hydration, elasticity and overall skin quality.

What hyaluronic acid contributes

HA binds water (up to 1,000× its weight), restoring moisture for plumper, smoother skin. In NEWEST, HA hydrates while polynucleotides get to work on repair.

Benefits you may notice

Fresher, more radiant skin
Improved elasticity and firmness
Softened fine lines and early wrinkles
Smoother texture and refined pores
More even look to pigmentation or post-acne marks

Treatment plan & downtime

Course: Typically 2–3 sessions a few weeks apart, then maintenance as advised. Downtime: Small bumps and mild redness can appear for 24–72 hours.

See all injectables

Who is it for?

Ideal for dehydrated, dull or more mature skin seeking subtle rejuvenation without added volume. Common areas: face, neck and décolleté. We’ll tailor your plan and can advise on pairing with RF microneedling, laser treatments, peels or bio-stimulators on separate protocols.

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FAQs

How many sessions will I need?

Most patients start with 2–3 sessions, spaced a few weeks apart. We’ll confirm after assessment.

When will I see results?

Hydration can feel improved within days. Regenerative changes develop over weeks as collagen is supported.

Is NEWEST a filler?

No — it’s a skin-quality treatment. HA hydrates while polynucleotides support repair and elasticity.

Is there downtime?

Expect small bumps at injection points for up to 72 hours, with possible mild redness/tenderness.

Can it help pigmentation or acne marks?

It can improve overall skin quality and evenness, softening the look of pigmentation or post-acne marks. Targeted treatments may also be advised.